Page 145 - 2018 SP Product Guide

lead to increased neuronal excitability. 376 Poisoning by ginkgotoxin can be counteracted by vitamin
undefined.) Strictly speaking this is a potential adverse effect (rather than a herb-drug interaction)
B6, 376 in cases of poisoning it is administered by intravenous injection. 377,378 Ginkgotoxin is present
million daily doses per year for more than two decades) no cases of epileptic seizure have been
as there is no pharmacokinetic data indicating an interaction for coadministration of Ginkgo and
particularly vulnerable). Ginkgotoxin is known to inhibit vitamin B6 phosphorylation, which may
According to the manufacturer, despite the extensive use of this special extract (more than 150
anticonvulsants in humans. An interaction is suggested though, because Ginkgo has been found
convulsions arising from ingestion of Ginkgo seed have been documented in Japan (infants are
in very small amounts in standardized Ginkgo leaf extracts, 379 but is below the detection limits
attributed to this extract. 380 (Ginkgo preparations associated with the above case reports were
in human plasma after oral doses (240 mg of 50:1 extract, equivalent to 12 g of dried leaf). 380
Ginkgotoxin (4’-O-methylpyridoxine) is present in substantial amounts in Ginkgo seed, and

some anticonvulsants.a to induce CYP2C19 activity (see entry for omeprazole), an enzyme involved in the metabolism of Analysis of over 320 000 patients in a German adverse drug reaction reporting system (1999- 2002) found no increase in prevalence of bleeding during Ginkgo intake compared to periods without Ginkgo in those taking anticoagulant or antiplatelet medication. 381 In a trial involving 3069 healthy volunteers treated for an ave

L. M. N. P. Q. R. S.

herbs and drugs, and the effect of drugs on the bioavailability of herbs are generally not included.
other authors have not been included. Due to the focus on safety, positive interactions between
considerable attention as potential issues. However, many theoretical concerns expressed by
This chart contains information the authors believe to be reliable or which has received

Chinese skullcap (Scutellaria baicalensis). 369 Research paper describes administration of Scutellaria radix. Trial authors confirm this was root of Analysis of Chinese skullcap root samples from Japan found the baicalin content varied from 3.5 to 12%. For a dose of 150 mg/day of baicalin, 1.2–4.3 g/day of dried root would be required. 370 Single-strength (freshly squeezed, 100%) cranberry juice is highly acidic and astringent, making it unpalatable.

NOTES * A. B. C. D. E. F. G. H. J. K. herb.

144 MediHerb Product Catalog 2018 • Herb-Drug Interaction Chart
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