Page 143 - 2018 SP Product Guide

Recommended Action Monitor (low level of risk). Monitor (very low level of risk). Monitor (low level of risk). Contraindicated especially for high-hyperforin extracts. Monitor (medium level of risk). Monitor (medium level of risk). Contraindicated. Monitor (low level of risk). Monitor (medium level of risk). Monitor (low level of risk). Hyperforin-rich extracts: Monitor (medium level of risk). Low-hyperforin extracts: Monitor (very low level of risk).

Cyclosporin: Case reports, 303-311 case series, 312,313 clinical studies. 270,314 Interaction is dependent upon the hyperforin
Clinical study with healthy volunteers, but glucose and insulin response to glucose loading were unchanged. 301
Clinical study with healthy volunteers: no effect, and glucose and insulin response to glucose loading were
Two clinical studies (healthy volunteers): no effect on pharmacokinetics, 281,283 but there was an increased

incidence of hypoglycemia in the trial using hyperforin-rich extract (33 mg/day). 283

Tacrolimus: Case report and clinical studies. 315-317 Clinical trial with healthy volunteers. No pharmacodynamic effect was observed. 318 Clinical study with healthy volunteers. No pharmacodynamic effect was observed Case report, 321 but clinical significance unclear. Clinical study (healthy volunteers): 322 pain scores were decreased when morphine co-administered with standardized extract at a dose of herb below those used to obtain an antide

Basis of Concern unchanged. 302 content. 306,316 (eg analgesic effect not altered). 319 Case reports. 320 Clinical trial. 323 affected. 332 Rosuvastatin: Case report. 342 Clinical study. 347

Potential Interaction Gliclazide: May reduce efficacy of drug by increased clearance. Repaglinide: May alter metabolism of drug. Tolbutamide: May affect blood glucose. Decreases drug levels. May decrease drug levels. May decrease drug levels. Decreases drug levels, possibly inducing withdrawal symptoms. May decrease efficacy. May potentiate effects of drug. May decrease drug levels. May increase metabolism and reduce effectiveness of drug. Decreases dru

Hypoglycemic drugs Immunosuppressives S-Ketamine (oral) Methylphenidate Morphine (oral) Oral contraceptives SSRIs eg paroxetine, trazodone, sertraline and other serotonergic agents eg nefazodone, venlafaxine

Drug Ivabradine Methadone Omeprazole Oxycodone Statin drugs Talinolol Theophylline Voriconazole Zolpidem

142 MediHerb Product Catalog 2018 • Herb-Drug Interaction Chart
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