Page 133 - 2018 SP Product Guide

Recommended Action Monitor (very low level of risk). Monitor (low level of risk at typical doses). Monitor (low level of risk). B Monitor (low level of risk). Monitor (low level of risk). Monitor (low level of risk). Monitor (low level of risk). Monitor (low level of risk). Monitor (low level of risk at typical doses). Monitor (low level of risk). Monitor (low level of risk). Monitor (low level of risk). Contraindicated. Monitor (medium level of risk) when

pressure in normotensive and hypertensive animals. 18,19 Clinical data from weight management trials: no effect
Theoretical concern based on ability of high doses of forskolin and standardized Coleus extract to lower blood
antiplatelet activity in an animal model (oral doses: standardized Coleus extract and forskolin). 16 More recent
Theoretical concern initially based on in vitro antiplatelet activity of active constituent forskolin, and in vivo
in vivo animal research: standardized Coleus extract reduced the anticoagulant activity of warfarin. 17
Clinical trial with healthy volunteers (water-based extract, A dried herb equivalent: 12 g/day). 14
Clinical study with healthy volunteers using 150 mg/day of isolated constituent (baicalin). 15

clinical studies conducted with hypotensive medication. on blood pressure in three trials, trend toward lower blood pressure in one small study. 20,21 No experimental or Theoretical concern based on ability of forskolin to activate increased intracellular cyclic AMP in vitro. 22 Clinical trials with healthy volunteers: effect on drug levels conflicting – increased (double-strength juice C , 240 mL tds; defined as a weak interaction D )

Basis of Concern Case reports. 13 undetectable viral load. 41 observed on plasma concentration. 47

Potential Interaction May reduce serum levels of thyroxine. May increase drug levels. May decrease drug levels. May alter response to drug. May potentiate effects of drug. May potentiate effects of drug. May increase drug levels. May increase side effects of drug. May alter INR (most frequently increase). May potentiate effect of drug. HIV non-nucleoside transcriptase inhibitors eg etravirine: May alter drug levels. HIV protease inhibitors eg darunavir: Ma

Celery Seed Apium graveolens Chinese Skullcap Scutellaria baicalensis Coleus Coleus forskohlii Antiplatelet and anticoagulant Hypotensive medication Cranberry Vaccinium macrocarpon Dong Quai Angelica sinensis, Angelica polymorpha Echinacea Echinacea angustifolia, Echinacea purpurea Immunosuppressant medication

Drug Thyroxine Losartan Rosuvastatin drugs Prescribed medication Midazolam Simvastatin Warfarin Warfarin Antiretroviral drugs Midazolam Digoxin

132 MediHerb Product Catalog 2018 • Herb-Drug Interaction Chart
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