Page 136 - 2018 SP Product Guide

Recommended Action Monitor (low level of risk). Monitor at doses of metformin > 1 g/day (medium level of risk). Reduce drug if necessary in conjunction with prescribing physician. Monitor (low level of risk). Monitor (low level of risk). Monitor at doses < 240 mg/day (medium level of risk). Contraindicated for higher doses. Monitor (low level of risk). Monitor (low level of risk). Monitor (low level of risk). Monitor (low level of risk). Monitor (low l

Basis of Concern Observation from aborted trial: hypoglycemia occurred in volunteers with normal glucose tolerance within 60 minutes. 110 Ginkgo 50:1 extract was administered as a single dose of 120 mg. 111 Clinical trial: elimination half-life was increased at doses of metformin 850 mg, three times a day. Effect not significant at doses to 500 mg, twice a day. Ginkgo 50:1 extract was administered as a single dose of 120 mg. 110 Clinical trial with healthy volunteer

Potential Interaction Glipizide: May cause hypoglycemia. Metformin: May enhance effectiveness of drug. Pioglitazone: May increase drug level. Tolbutamide: May decrease effectiveness of drug. May increase drug levels or side effects. May decrease drug levels. May decrease drug levels. May increase drug levels. May potentiate effect of drug on displacing bilirubin. May increase drug level. Green Tea Camellia sinensis (See also Polyphenol-containing herbs

Hypoglycemic drugs Golden Seal N Hydrastis canadensis Drugs which displace the protein binding of bilirubin eg phenylbutazone Boronic acid-based protease inhibitors eg bortezomib Immunosuppressives Statin drugs eg simvastatin

Drug Nifedipine Omeprazole Statin drugs Talinolol Midazolam Folate Sildenafil Sunitinib Warfarin

Herb-Drug Interaction Chart • MediHerb Product Catalog 2018 135
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