Page 137 - 2018 SP Product Guide

Recommended Action Monitor (low level of risk). Monitor (low level of risk). Prescribe cautiously and monitor blood sugar regularly. Warn patient about possible hypoglycemic effects. Reduce drug if necessary in conjunction with prescribing physician. Monitor (low level of risk). Contraindicated unless under close supervision. Monitor (very low level of risk). Monitor (low level of risk). Monitor (low level of risk). Monitor (low level of risk). Monitor (lo

Basis of Concern Clinical studies indicate a (beneficial) synergistic effect. 129,130 Pharmacokinetics not affected in a clinical study (healthy volunteers). 131 Controlled trials where drugs known to be taken by all or many heart disease patients: blood pressure decreased significantly (2 trials), 132,133 decreased nonsignificantly (1 trial) 134 and was unchanged (1 trial). 135 Significant decrease in blood pressure observed in diabetics taking hypotensive drugs (1

Potential Interaction Hawthorn Crataegus monogyna, Crataegus laevigata (C. oxyacantha) (See also Tannin-containing herbs) May increase effectiveness of drug. May increase effectiveness of drug. Hypoglycemic herbs eg Gymnema sylvestre (See also Ginkgo, Korean Ginseng, Milk Thistle, St John’s Wort) May potentiate hypoglycemic activity of drug. Potentiation of drug effects. Possible dopamine antagonist effects. General: May decrease effectiveness of drug. Nifedi

Hypotensive drugs Hypoglycemic drugs including insulin Kava Piper methysticum CNS depressants eg alcohol, barbiturates, benzodiazepines L-dopa and other Parkinson’s disease Korean Ginseng Panax ginseng Antihypertensive medications including nifedipine Antiplatelet and anticoagulant Cancer chemotherapeutic drugs CNS stimulants HIV integrase inhibitors

Drug Digoxin treatments drugs eg imatinib eg raltegravir

136 MediHerb Product Catalog 2018 • Herb-Drug Interaction Chart
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